Anti-NUDT15 Polyclonal Antibody
Cat: K005789P
Summary:
| 【Product name】：Anti-NUDT15 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：55270 | 【Swiss Prot】：Q9NV35 |
| 【Species reactivity】：Human,Mouse,Rat | |
| 【Tested applications】：IHC,WB | |
| 【Immunogen】：Recombinant protein of human NUDT15 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regulator of thiopurine activation and toxicity. Mutations in this gene result in poor metabolism of thiopurines, and are associated with thiopurine-induced early leukopenia. Multiple pseudogenes of this gene have been identified.
Verified picture:
Western blot analysis with NUDT15 antibody diluted at 1:1000;Lane: HT-29 Raji.
Immunohistochemistry of paraffin-embedded human liver using NUDT15 antibody at dilution of 1:100 (x40 lens).