Anti-HIRA Polyclonal Antibody
Cat: K005855P
Summary:
| 【Product name】：Anti-HIRA Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：7290 | 【Swiss Prot】：P54198 |
| 【Species reactivity】：Human | |
| 【Tested applications】：IHC,WB | |
| 【Immunogen】：Recombinant protein of human HIRA | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development.
Verified picture:
Western blot analysis with HIRA antibody diluted at 1:1000;Lane: 293T HepG2 HeLa.
Immunohistochemistry of paraffin-embedded human gastric cancer using HIRA antibody at dilution of 1:100 (x40 lens).