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Anti-CD33 Polyclonal Antibody
Cat: K006979P
Summary:
【Product name】:Anti-CD33 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:945 【Swiss Prot】:P20138
【Species reactivity】:Mouse,Human
【Tested applications】:IHC,WB
【Immunogen】:Recombinant protein of human CD33
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
CD33?or Siglec-3 is a?transmembrane receptor?expressed on cells of?myeloid?lineage.?It is usually considered myeloid-specific, but it can also be found on some?lymphoid?cells. Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
Verified picture:
Western blot analysis with CD33 antibody diluted at 1:400;Lane:Hela,NIH/3T3 cells
Immunohistochemistry of paraffin-embedded Human thyroid cancer with CD331 antibody diluted at 1:30