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Anti-PLA2G4A Polyclonal Antibody
Cat: K006997P
Summary:
【Product name】:Anti-PLA2G4A Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:5321 【Swiss Prot】:P47712
【Species reactivity】:Mouse,Rat,Human
【Tested applications】:IHC,WB
【Immunogen】:Recombinant protein of human PLA2G4A
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.
Verified picture:
Western blot analysis with PLA2G4A antibody diluted at 1:1000; Lane: 293T,THP-1,HT29
Immunohistochemistry of paraffin-embedded Human thyroid cancer with PLA2G4A antibody diluted at 1:50