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Anti-CYFIP2 Polyclonal Antibody - HRP
Cat: K007003P - HRP
Summary:
【Product name】:Anti-CYFIP2 Polyclonal Antibody - HRP 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:26999 【Swiss Prot】:Q96F07
【Species reactivity】:Mouse,Human
【Tested applications】:WB,IHC
【Recommended dilution】:WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200
【Immunogen】:Recombinant protein of human CYFIP2
【Storage】:Store at -20℃. Avoid freeze / thaw cycles.
Background:
CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.
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