Anti-SKIL Polyclonal Antibody
Cat: K007186P
Summary:
| 【Product name】：Anti-SKIL Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：6498 | 【Swiss Prot】：P12757 |
| 【Species reactivity】：Mouse,Human | |
| 【Tested applications】：IHC,WB | |
| 【Immunogen】：Recombinant protein of human SKIL | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene.
Verified picture:
Western blot analysis with SKIL antibody diluted at 1:450; Lane: Huvec
Immunohistochemistry of paraffin-embedded Human esophageal cancer with SKIL antibody diluted at 1:50