Anti-EEA1 Polyclonal Antibody - HRP
Cat: K007365P - HRP
Summary:
| 【Product name】：Anti-EEA1 Polyclonal Antibody - HRP | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：8411 | 【Swiss Prot】：Q15075 |
| 【Species reactivity】：Mouse,Human | |
| 【Tested applications】：WB | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human EEA1 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking. The carboxy terminus of EEA1 contains a FYVE domain which binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to early endosomes. The stable association of EEA1 with the endosomal membrane is regulated by PI3 kinase, Rab5 and calcium/calmodulin. Once on the membrane, EEA1 interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion.
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