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Anti-PTN Polyclonal Antibody - SAlexa Fluor 680
Cat: K007623P - SAlexa Fluor 680
Summary:
【Product name】:Anti-PTN Polyclonal Antibody - SAlexa Fluor 680 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:5764 【Swiss Prot】:P21246
【Species reactivity】:Mouse,Rat,Human
【Tested applications】:WB
【Immunogen】:A synthetic peptide of human PTN
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
Pleiotrophin?(PTN) also known as?heparin-binding brain mitogen?(HBBM) or?heparin-binding growth factor 8?(HBGF-8) or?neurite growth-promoting factor 1?(NEGF1) or?heparin affinity regulatory peptide?(HARP) or?heparin binding growth associated molecule?(HB-GAM) is a?protein?that in humans is encoded by the?PTNgene.?Pleiotrophin is an 18-kDa?growth factor?that has a high affinity for?heparin. It is structurally related to?midkine?and?retinoic acid induced heparin-binding protein. Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
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