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Anti-CAV1 Polyclonal Antibody
Cat: K007672P
Summary:
【Product name】:Anti-CAV1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:857 【Swiss Prot】:Q03135
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:1000-5000. IHC 1:50-200.
【Immunogen】:A synthetic peptide of human CAV1
【Public Immunogen Range】:2-15aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.
Verified picture:
Western blot analysis with CAV1 antibody diluted at 1:3000; Lane:A549,HeLa,Mouse lung,Rat heart,Mouse heart,NIH3T3,Mouse liver
Immunohistochemistry of paraffin-embedded Human esophageal cancer tissue with CAV1 antibody diluted at 1:50