Anti-EID3 Polyclonal Antibody - Biotin
Cat: K007705P - Biotin
Summary:
| 【Product name】：Anti-EID3 Polyclonal Antibody - Biotin | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：493861 | 【Swiss Prot】：Q8N140 |
| 【Species reactivity】：Mouse,Human | |
| 【Tested applications】：WB ELISA IHC ICC | |
| 【Recommended dilution】：WB 1:50-200. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human EID3 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
EID3?is highly expressed in testis and shows homology to a region of EID1 implicated in binding to CBP/p300. EID3 acts as a potent inhibitor of nuclear receptor transcriptional activity by a mechanism that is independent of direct interactions with nuclear receptors, including SHP. Furthermore, EID3 directly binds to and blocks the SRC-1 interacting domain of CBP, which has been implicated to act as the interaction surface for nuclear receptor co-activators. Consistent with this idea, EID3 prevents recruitment of CBP to a natural nuclear receptor-regulated promoter.
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