Anti-EID3 Polyclonal Antibody - SAlexa Fluor 532
Cat: K007705P - SAlexa Fluor 532
Summary:
| 【Product name】：Anti-EID3 Polyclonal Antibody - SAlexa Fluor 532 | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：493861 | 【Swiss Prot】：Q8N140 |
| 【Species reactivity】：Mouse,Human | |
| 【Tested applications】：IHC,WB | |
| 【Immunogen】：A synthetic peptide of human EID3 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
EID3?is highly expressed in testis and shows homology to a region of EID1 implicated in binding to CBP/p300. EID3 acts as a potent inhibitor of nuclear receptor transcriptional activity by a mechanism that is independent of direct interactions with nuclear receptors, including SHP. Furthermore, EID3 directly binds to and blocks the SRC-1 interacting domain of CBP, which has been implicated to act as the interaction surface for nuclear receptor co-activators. Consistent with this idea, EID3 prevents recruitment of CBP to a natural nuclear receptor-regulated promoter.
Verified picture: