下载
Anti-CASP4 Polyclonal Antibody - HRP
Cat: K007971P - HRP
Summary:
【Product name】:Anti-CASP4 Polyclonal Antibody - HRP 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:837 【Swiss Prot】:P49662
【Species reactivity】:Human
【Tested applications】:IHC,WB
【Recommended dilution】:WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200
【Immunogen】:A synthetic peptide of human CASP4
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
Verified picture: