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Anti-ADRA2A Polyclonal Antibody
Cat: K008009P
Summary:
【Product name】:Anti-ADRA2A Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:150 【Swiss Prot】:P08913
【Species reactivity】:Human,Rat,Mouse
【Tested applications】:IHC
【Immunogen】:A synthetic peptide of human ADRA2A
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.?
Verified picture:
Immunohistochemistry of paraffin-embedded Human skin cancer with ADRA2A antibody diluted at 1:30