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Anti-LPIN1 Polyclonal Antibody
Cat: K008030P
Summary:
【Product name】:Anti-LPIN1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:23175 【Swiss Prot】:Q14693
【Species reactivity】:Human,Mouse
【Tested applications】:WB,IHC
【Immunogen】:A synthetic peptide of human LPIN1
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their full-length structures have not been determined.
Verified picture:
Western blot analysis with LPIN1 antibody diluted at 1:850; Lane: K-562,HepG2
Immunohistochemistry of paraffin-embedded Human stomach cancer with LPIN1 antibody diluted at 1:50