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Anti-TJP1 Polyclonal Antibody - SAlexa Fluor 680
Cat: K008065P - SAlexa Fluor 680
Summary:
【Product name】:Anti-TJP1 Polyclonal Antibody - SAlexa Fluor 680 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:7082 【Swiss Prot】:Q07157
【Species reactivity】:Human,Rat,Mouse
【Tested applications】:IHC
【Immunogen】:A synthetic peptide of human TJP1
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family of proteins, and acts as a tight junction adaptor protein that also regulates adherens junctions. Tight junctions regulate the movement of ions and macromolecules between endothelial and epithelial cells. The multidomain structure of this scaffold protein, including a postsynaptic density 95/disc-large/zona occludens (PDZ) domain, a Src homology (SH3) domain, a guanylate kinase (GuK) domain and unique (U) motifs all help to co-ordinate binding of transmembrane proteins, cytosolic proteins, and F-actin, which are required for tight junction function. Alternative splicing results in multiple transcript variants encoding different isoforms.
Verified picture: