Anti-MSH4 Polyclonal Antibody
Cat: K008191P
Summary:
| 【Product name】：Anti-MSH4 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：4438 | 【Swiss Prot】：O15457 |
| 【Species reactivity】：Human,Mouse | |
| 【Tested applications】：IHC | |
| 【Immunogen】：Recombinant protein of human MSH4 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
This gene encodes a member of the DNA mismatch repair mutS family. This member is a meiosis-specific protein that is not involved in DNA mismatch correction, but is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis I. This protein and MSH5 form a heterodimer which binds uniquely to a Holliday Junction and its developmental progenitor, thus provoking ADP-ATP exchange, and stabilizing the interaction between parental chromosomes during meiosis double-stranded break repair.
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer with MSH4 antibody diluted at 1:50