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Anti-NAIF1 Polyclonal Antibody
Cat: K008198P
Summary:
【Product name】:Anti-NAIF1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:203245 【Swiss Prot】:Q69YI7
【Species reactivity】:Human,Mouse
【Tested applications】:IHC
【Immunogen】:Recombinant protein of human NAIF1
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
Human NAIF1 is located on chromosome 9q34.11 and encodes 327 amino acids with a homeodomain-like region and two nuclear localization signals at its N-terminal region. NAIF1 is conserved across diverse species, including human, mouse, crab-eating macaque, dog, chicken and frog, and shares no obvious homology to any known genes or proteins. NAIF1 was predominantly localized in the nucleus. Overexpression of NAIF1 inhibited cell growth and induced apoptosis. Furthermore, NAIF1 transfection caused both decreases in mitochondrial membrane potential and caspase-3 activation. In summary, NAIF1 is a nuclear protein that induces apoptosis when overexpressed.
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer with NAIF1 antibody diluted at 1:50