Anti-TAB1 Polyclonal Antibody - SAlexa Fluor 750
Cat: K008371P - SAlexa Fluor 750
Summary:
| 【Product name】：Anti-TAB1 Polyclonal Antibody - SAlexa Fluor 750 | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：10454 | 【Swiss Prot】：Q15750 |
| 【Species reactivity】：Mouse,Human | |
| 【Tested applications】：IHC | |
| 【Immunogen】：Recombinant protein of human TAB1 | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1.
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