Anti-CASP3 Polyclonal Antibody
Cat: K101291P
Summary:
| 【Product name】：Anti-CASP3 Polyclonal Antibody | 【Source】：Rabbit | ||
| 【Isotype】：IgG | |||
| 【Gene ID】：836 | 【Swiss Prot】：P42574 | ||
| 【Species reactivity】：Human,Mouse | |||
| 【Tested applications】：WB,IHC | 【Tested applications】：IF | ||
| 【Immunogen】：A synthetic peptide of human CASP3 | |||
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |||
Background:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Verified picture:
Western blot analysis with CASP3 antibody diluted at 1:1000
Immunohistochemistry of paraffin-embedded Colorectal cancer(hu) using CASP3 at dilution of 1:100 (x100 lens,x200 lens).