Anti-ITGA2B Polyclonal Antibody - SAlexa Fluor 488
Cat: K106413P - SAlexa Fluor 488
Summary:
| 【Product name】：Anti-ITGA2B Polyclonal Antibody - SAlexa Fluor 488 | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：3674 | 【Swiss Prot】：P08514 |
| 【Species reactivity】：Human | |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human ITGA2B | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
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