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Anti-KRT18 Polyclonal Antibody - SAlexa Fluor 660
Cat: K106590P - SAlexa Fluor 660
Summary:
【Product name】:Anti-KRT18 Polyclonal Antibody - SAlexa Fluor 660 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:3875 【Swiss Prot】:P05783
【Species reactivity】:Human,Rat,Mouse
【Tested applications】:IHC,WB
【Immunogen】:Recombinant protein of human KRT18
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
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