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Anti-CIP2A Polyclonal Antibody - Cy7
Cat: K106617P - Cy7
Summary:
【Product name】:Anti-CIP2A Polyclonal Antibody - Cy7 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:57650 【Swiss Prot】:Q8TCG1
【Species reactivity】:Human
【Tested applications】:WB
【Immunogen】:Recombinant protein of human CIP2A
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
Cancerous inhibitor of protein phosphatase 2A (CIP2A), also designated p90 autoantigen or KIAA1524, is a single-pass membrane protein that exhibits oncogenic activity. CIP2A is known to inhibit PP2A (protein phosphatase 2A) dephosphorylation of c-Myc, thereby stabilizing c-Myc (an oncogenic transcription factor) and promoting tumor formation and malignant cell growth. PP2A is a trimeric protein complex consisting of three subunits: a scaffold subunit, a catalytic subunit and a regulatory subunit. CIP2A specifically interacts with the catalytic subunit of PP2A to inhibit its activity. Inhibition of PP2A activity is a crucial step allowing for the progression of human cell transformation. Further supporting its role as an oncoprotein, CIP2A is known to be overexpressed in colon, gastric, and head and neck squamous cell carcinomas.
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