Anti-BAX Polyclonal Antibody - HRP
Cat: K106624P - HRP
Summary:
| 【Product name】：Anti-BAX Polyclonal Antibody - HRP | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：581 | 【Swiss Prot】：Q07812 |
| 【Species reactivity】：Human | |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human BAX | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.7
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