Anti-SMAD7 Polyclonal Antibody - SAlexa Fluor 488
Cat: K106646P - SAlexa Fluor 488
Summary:
| 【Product name】：Anti-SMAD7 Polyclonal Antibody - SAlexa Fluor 488 | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：4092 | 【Swiss Prot】：O15105 |
| 【Species reactivity】：Human | |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human SMAD7 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Verified picture: