Anti-CNTN1 Polyclonal Antibody
Cat: K107050P
Summary:
| 【Product name】：Anti-CNTN1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：1272 | 【Swiss Prot】：Q12860 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:100-300. | |
| 【Immunogen】：A synthetic peptide of human CNTN1 | |
| 【Public Immunogen Range】：310-360/1018aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
Verified picture:
Immunohistochemistry of paraffin-embedded Human skin cancer with CNTN1 antibody diluted at 1:200.