Anti-CNTN1 Polyclonal Antibody - RBITC
Cat: K107050P - RBITC
Summary:
| 【Product name】：Anti-CNTN1 Polyclonal Antibody - RBITC | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：1272 | 【Swiss Prot】：Q12860 |
| 【Species reactivity】：Human,Rat,Mouse | |
| 【Tested applications】：WB ELISA IHC ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human CNTN1 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
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