Anti-TERF1 Polyclonal Antibody
Cat: K107057P
Summary:
| 【Product name】：Anti-TERF1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：7013 | 【Swiss Prot】：P54274 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human TERF1 | |
| 【Public Immunogen Range】：305-355/439aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.
Verified picture:
Immunohistochemistry of paraffin-embedded Human ovarian cancer with TERF1 antibody diluted at 1:100.