Anti-DTX2 Polyclonal Antibody
Cat: K008450P
Summary:
| 【Product name】：Anti-DTX2 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：113878 | 【Swiss Prot】：Q86UW9 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:10-50. | |
| 【Immunogen】：Recombinant protein of human DTX2 | |
| 【Public Immunogen Range】：303-622aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
DTX2 functions as an E3 ubiquitin ligase. Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
Verified picture:
Immunohistochemistry of paraffin-embedded Human liver cancer with DTX2 antibody diluted at 1:40.