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Anti-FOXK1 Polyclonal Antibody - RBITC
Cat: K008826P - RBITC
Summary:
【Product name】:Anti-FOXK1 Polyclonal Antibody - RBITC 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:221937 【Swiss Prot】:P85037
【Species reactivity】:Human,Mouse
【Tested applications】:WB ELISA IHC ICC IF
【Recommended dilution】:ICC 1:50-200. IF 1:50-200
【Immunogen】:A synthetic peptide of human FOXK1
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
Transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin gene. Important regulatory factor of the myogenic progenitor cell population. Involved in the cell cycle process, promotes proliferation by repressing Foxo4 transcriptional activity and the cyclin-dependent kinase inhibitor, p21CIP, in the myogenic progenitor cells. Represses myogenic differentiation by inhibiting MEFC acitivity. Has a role in remodeling processes of adult muscles that occur in response to physiological stimuli. Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair. Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus. Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression.
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