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Anti-LRP6 Polyclonal Antibody - SAlexa Fluor 350
Cat: K008862P - SAlexa Fluor 350
Summary:
【Product name】:Anti-LRP6 Polyclonal Antibody - SAlexa Fluor 350 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:4040 【Swiss Prot】:O75581
【Species reactivity】:Human,Mouse
【Tested applications】:ICC IF
【Recommended dilution】:ICC 1:50-200. IF 1:50-200
【Immunogen】:A synthetic peptide of human LRP6
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.
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