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Anti-ACO1 Polyclonal Antibody
Cat: K008960P
Summary:
【Product name】:Anti-ACO1 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:48 【Swiss Prot】:P21399
【Tested applications】:WB
【Recommended dilution】:WB 1:1000-5000.
【Immunogen】:A synthetic peptide of human ACO1
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Verified picture:
Western blot analysis with ACO1 antibody diluted at 1:3000;Lane: Mouse liver,Mouse kidney.