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Anti-CDK2AP1 Polyclonal Antibody - HRP
Cat: K008657P - HRP
Summary:
【Product name】:Anti-CDK2AP1 Polyclonal Antibody - HRP 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:8099 【Swiss Prot】:O14519
【Species reactivity】:Human,Mouse
【Tested applications】:IHC
【Recommended dilution】:WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200
【Immunogen】:Recombinant protein of human CDK2AP1
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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