Anti-DENND1B Polyclonal Antibody - SAlexa Fluor 568
Cat: K008677P - SAlexa Fluor 568
Summary:
| 【Product name】：Anti-DENND1B Polyclonal Antibody - SAlexa Fluor 568 | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：163486 | 【Swiss Prot】：Q6P3S1 |
| 【Species reactivity】：Human,Mouse | |
| 【Tested applications】：WB | |
| 【Immunogen】：Recombinant protein of human DENND1B | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Clathrin (see MIM 118955)-mediated endocytosis is a major mechanism for internalization of proteins and lipids. Members of the connecdenn family, such as DENND1B, function as guanine nucleotide exchange factors (GEFs) for the early endosomal small GTPase RAB35 (MIM 604199) and bind to clathrin and clathrin adaptor protein-2 (AP2; see MIM 601024). Thus, connecdenns link RAB35 activation with the clathrin machinery.
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