Anti-ITM2B Polyclonal Antibody - SAlexa Fluor 594
Cat: K107269P - SAlexa Fluor 594
Summary:
| 【Product name】：Anti-ITM2B Polyclonal Antibody - SAlexa Fluor 594 | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：9445 | 【Swiss Prot】：Q9Y287 |
| 【Species reactivity】：Human | |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：Recombinant protein of human ITM2B | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
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