Anti-NPRL3 Polyclonal Antibody - SAlexa Fluor 532
Cat: K107372P - SAlexa Fluor 532
Summary:
| 【Product name】：Anti-NPRL3 Polyclonal Antibody - SAlexa Fluor 532 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：8131 | 【Swiss Prot】：Q12980 |
| 【Tested applications】：WB;IHC;IF,IHC,WB,IF | |
| 【Recommended dilution】：WB 1:5000-8000. IHC 1:100-300. IF 1:50-200. | |
| 【Immunogen】：Recombinant protein of human NPRL3 | |
| 【Public Immunogen Range】：391-569aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
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