Anti-E2F6 Polyclonal Antibody
Cat: K107468P
Summary:
| 【Product name】：Anti-E2F6 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：1876 | 【Swiss Prot】：O75461 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human E2F6 | |
| 【Public Immunogen Range】：195-245/281aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase.
Verified picture:
Immunohistochemistry of paraffin-embedded Human esophageal cancer with E2F6 antibody diluted at 1:100.
Immunohistochemistry of paraffin-embedded Human lung cancer with E2F6 antibody diluted at 1:100.