Anti-MBNL3 Polyclonal Antibody - SAlexa Fluor 405
Cat: K107495P - SAlexa Fluor 405
Summary:
| 【Product name】：Anti-MBNL3 Polyclonal Antibody - SAlexa Fluor 405 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：55796 | 【Swiss Prot】：Q9NUK0 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:8000-12000. IHC 1:25-100. | |
| 【Immunogen】：A synthetic peptide of human MBNL3 | |
| 【Public Immunogen Range】：5-55/354aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
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