下载
Anti-SETD2 Polyclonal Antibody
Cat: K000379P
Summary:
【Product name】:Anti-SETD2 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:29072 【Swiss Prot】:Q9BYW2
【Tested applications】:IF,WB,IP
【Recommended dilution】:WB 1:500-1000. IF 1:50-200. IP 0.5μg-4μg.
【Immunogen】:A synthetic peptide of human SETD2
【Public Immunogen Range】:2475-2564aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.
Verified picture: