Anti-IL1B Polyclonal Antibody
Cat: K107559P
Summary:
| 【Product name】：Anti-IL1B Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：3553 | 【Swiss Prot】：P01584 |
| 【Tested applications】：IHC,IF | |
| 【Recommended dilution】：IHC 1:50-200. IF 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human IL1B | |
| 【Public Immunogen Range】：195-245/269aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
Verified picture:
Immunohistochemistry of paraffin-embedded Human lung cancer with IL1B antibody diluted at 1:100.
Immunohistochemistry of paraffin-embedded Human stomach cancer with IL1B antibody diluted at 1:100.
Immunofluorescence analysis of A431 cells using IL1B antibody diluted at 1:100.