Anti-EZH1 Polyclonal Antibody - Cy3.5
Cat: K107561P - Cy3.5
Summary:
| 【Product name】：Anti-EZH1 Polyclonal Antibody - Cy3.5 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：2145 | 【Swiss Prot】：Q92800 |
| 【Tested applications】：WB,IF,IHC,IP | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:100-300. IF 1:50-200. IP 1:50-500. | |
| 【Immunogen】：A synthetic peptide of human EZH1 | |
| 【Public Immunogen Range】：50-100/747aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
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