Anti-PHD2 Polyclonal Antibody - FITC
Cat: K107563P - FITC
Summary:
| 【Product name】：Anti-PHD2 Polyclonal Antibody - FITC | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：54583 | 【Swiss Prot】：Q9GZT9 |
| 【Species reactivity】：Human,Mouse,Rat | |
| 【Tested applications】：ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human PHD2 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).
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