Anti-PHLDA3 Polyclonal Antibody - SAlexa Fluor 640
Cat: K107593P - SAlexa Fluor 640
Summary:
| 【Product name】：Anti-PHLDA3 Polyclonal Antibody - SAlexa Fluor 640 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：23612 | 【Swiss Prot】：Q9Y5J5 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human PHLDA3 | |
| 【Public Immunogen Range】：25-75/127aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.
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