下载
Anti-CDKAP1 Polyclonal Antibody - SAlexa Fluor 680
Cat: K107629P - SAlexa Fluor 680
Summary:
【Product name】:Anti-CDKAP1 Polyclonal Antibody - SAlexa Fluor 680 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:8099 【Swiss Prot】:O14519
【Species reactivity】:Human,Mouse
【Tested applications】:WB,IHC
【Immunogen】:A synthetic peptide of human CDKAP1
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Verified picture: