Anti-NALP4 Polyclonal Antibody
Cat: K107691P
Summary:
| 【Product name】：Anti-NALP4 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：147945 | 【Swiss Prot】：Q96MN2 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of human NALP4 | |
| 【Public Immunogen Range】：510-560/994aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.
Verified picture:
Immunohistochemistry of paraffin-embedded Human colorectal cancer with NALP4 antibody diluted at 1:100.