Anti-AIM2 Polyclonal Antibody - Cy7
Cat: K107823P - Cy7
Summary:
| 【Product name】：Anti-AIM2 Polyclonal Antibody - Cy7 | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：9447 | 【Swiss Prot】：O14862 |
| 【Species reactivity】：Human | |
| 【Tested applications】：WB,IHC | |
| 【Immunogen】：A synthetic peptide of Human AIM2 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
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