Anti-TGS1 Polyclonal Antibody
Cat: K107885P
Summary:
| 【Product name】：Anti-TGS1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | |
| 【Gene ID】：96764 | 【Swiss Prot】：Q96RS0 |
| 【Species reactivity】：Human | |
| 【Tested applications】：IHC | |
| 【Immunogen】：Recombinant protein of human TGS1 | |
| 【Storage】：Store at -20℃, avoid freeze/thaw cycles. | |
Background:
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies . Plays a role in transcriptional regulation.
Verified picture:
Immunohistochemistry of paraffin-embedded Human pancreatic cancer with TGS1 antibody diluted at 1:200.