Anti-HSD11B1 Polyclonal Antibody
Cat: K107931P
Summary:
| 【Product name】：Anti-HSD11B1 Polyclonal Antibody | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：3290 | 【Swiss Prot】：P28845 |
| 【Tested applications】：WB,IHC | |
| 【Recommended dilution】：WB 1:1000-3000. IHC 1:50-200. | |
| 【Immunogen】：A synthetic peptide of Human HSD11B1 | |
| 【Public Immunogen Range】：242-292/292aa | |
| 【Storage】：Store at -20℃. Avoid freeze/thaw cycles. | |
Background:
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.
Verified picture:
Western blot analysis with HSD11B1 antibody diluted at 1:2000;Lane: Raji,Rat liver.
Immunohistochemistry of paraffin-embedded Human endometrial cancer with HSD11B1 antibody diluted at 1:100.