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Anti-RAB11B Polyclonal Antibody - SAlexa Fluor 532
Cat: K108052P - SAlexa Fluor 532
Summary:
【Product name】:Anti-RAB11B Polyclonal Antibody - SAlexa Fluor 532 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:9230 【Swiss Prot】:Q15907
【Species reactivity】:Human,Rat,Mouse
【Tested applications】:WB
【Immunogen】:A synthetic peptide of Human RAB11B
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The small Rab GTPase RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
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