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Anti-RYBP Polyclonal Antibody - SAlexa Fluor 660
Cat: K108142P - SAlexa Fluor 660
Summary:
【Product name】:Anti-RYBP Polyclonal Antibody - SAlexa Fluor 660 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:23429 【Swiss Prot】:Q8N488
【Tested applications】:WB,IHC
【Recommended dilution】:WB 1:1000-3000. IHC1:50-200.
【Immunogen】:Recombinant protein of human RYBP
【Public Immunogen Range】:1-228aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as
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