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Anti-ZAP70 Polyclonal Antibody
Cat: K108226P
Summary:
【Product name】:Anti-ZAP70 Polyclonal Antibody 【Source】:Rabbit
【Isotype】:IgG
【Gene ID】:7535 【Swiss Prot】:P43403
【Species reactivity】:Human,Rat,Mouse
【Tested applications】:WB
【Immunogen】:Recombinant protein of human ZAP70
【Storage】:Store at -20℃, avoid freeze/thaw cycles.
Background:
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Verified picture:
Western blot analysis with ZAP70 antibody diluted at 1:4000;Lane: Jurkat.